Abstract | BACKGROUND AND OBJECTIVE: METHODS: Controlled-release oxycodone tablets were vaginally administered to 36 female patients with moderate to severe cancer pain. The initial dose was 10 mg every 12 h to patients who had never taken opioid analgesics; former dose continued to patients switching to vaginal route from oral route. RESULTS: Among the 36 patients, six had complete relief of cancer pain, 20 had significant relief, four had moderate relief, and four had slight relief, two had no relief. The relief rate of cancer pain was 83.3%. The mean time for onset of analgesic effect was 49 min; the mean duration of analgesic effect was 13.8 h. Main adverse event was vaginal burning sensation in nine (25.0%) patients. No patient discontinued vaginal administration because of adverse events. CONCLUSION:
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Authors | Xia Zhang, Xin-Jian Ruan, Chang Liu, Zhong-He Yu |
Journal | Ai zheng = Aizheng = Chinese journal of cancer
(Ai Zheng)
Vol. 28
Issue 7
Pg. 740-2
(Jul 2009)
China |
PMID | 19624902
(Publication Type: Clinical Trial, English Abstract, Journal Article)
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Chemical References |
- Analgesics, Opioid
- Delayed-Action Preparations
- Oxycodone
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Topics |
- Administration, Intravaginal
- Adult
- Aged
- Analgesics, Opioid
(administration & dosage, adverse effects, therapeutic use)
- Bone Neoplasms
(complications, secondary)
- Breast Neoplasms
(complications)
- Delayed-Action Preparations
- Female
- Humans
- Lung Neoplasms
(complications)
- Middle Aged
- Oxycodone
(administration & dosage, adverse effects, therapeutic use)
- Pain
(drug therapy, etiology)
- Stomach Neoplasms
(complications)
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