Abstract | BACKGROUND/PURPOSE: Videocapillaroscopy (VCP) can be used to explore microcirculatory modifications in skin diseases. Psoriasis presents a specifically altered capillaroscopic pattern with 'bushy' capillaries and a disarranged microangioarchitecture. The aim of the present study is to compare the clinical and capillaroscopic modifications of a psoriatic target lesion during topical therapy. METHODS: RESULTS: Topical therapy with combined betamethasone dipropionate and calcipotriol induced a higher decrease in erythema, infiltration and desquamation (P<0.001), and a significant reduction of the mean 'bush' diameter (P<0.001) and capillary number/mm(2) (P<0.05) compared with betamethasone and calcipotriol alone. Microvascular restoration to a normal pattern, as detected by VCP, was faster than clinical improvement (P<0.05). CONCLUSION: Videocapillaroscopy is an easily executable and non-invasive technique that detects early microcirculatory changes in psoriasis during topical therapy.
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Authors | Paolo Rosina, Andrea Giovannini, Paolo Gisondi, Giampiero Girolomoni |
Journal | Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
(Skin Res Technol)
Vol. 15
Issue 2
Pg. 135-8
(May 2009)
ISSN: 1600-0846 [Electronic] England |
PMID | 19622121
(Publication Type: Controlled Clinical Trial, Journal Article)
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Chemical References |
- Dermatologic Agents
- calcipotriene
- betamethasone-17,21-dipropionate
- Betamethasone
- Calcitriol
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Topics |
- Administration, Topical
- Adult
- Aged
- Betamethasone
(administration & dosage, analogs & derivatives)
- Calcitriol
(administration & dosage, analogs & derivatives)
- Capillaries
(drug effects, pathology)
- Dermatologic Agents
(administration & dosage)
- Dermoscopy
(methods)
- Drug Therapy, Combination
- Female
- Humans
- Male
- Microcirculation
(drug effects)
- Microscopic Angioscopy
(methods)
- Middle Aged
- Psoriasis
(drug therapy, pathology)
- Skin
(blood supply, drug effects, pathology)
- Treatment Outcome
- Young Adult
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