[Use of a low dose prostaglandin F2 alpha in bitches].

Abstract

The dosage of Prostaglandin F2 alpha used until the present (100, 250 and 1000 micrograms/kg bw), in order to treat pyometra in the bitch, was accompanied with side effects such as salivation, vomiting and diarrhea. In the present work, the efficiency of low dose Prostaglandin (20 micrograms/kg bw) was examined in two different groups of patients: Group 1: Included 9 bitches pregnant for a period of 5-7 weeks duration. Initially the bitches were treated 3 or 4 times per day with Prostaglandin F2 alpha. In these cases abortion took place within 4 to 11 days. Group 2: 12 dogs, suffering from pyometra, were treated 3 times per day with PGF2 alpha for 8 days. In 9 dogs the pyometra resolved and the bitches came in estrus 2-5 months after treatment. 7 bitches have been mated and 6 of these gave birth to healthy litters. During a follow-up period of at least 10 months there has not been a reoccurrence of pyometra. In 3 out of the 12 dogs the uteri were still enlarged after 8 days of treatment. These bitches underwent ovariohysterectomy and a cystic hyperplasia of the endometrium was diagnosed histologically. The low dose (20 micrograms/kg BW) Prostaglandin F2 alpha induced in all dogs the expulsion of the uterine contents. Side effects during the treatment were not observed.

• Authors: M Hubler, S Arnold, M Casal, M Flückiger, B Hauser, L Corboz, P Rüsch
• Journal: Schweizer Archiv fur Tierheilkunde (Schweiz Arch Tierheilkd) Vol. 133 Issue 7 Pg. 323-9 ( 1991) ISSN: 0036-7281 [Print] Switzerland
• Vernacular Title: Anwendung von niedrig dosiertem Prostaglandin F2 alpha bei Hündinnen.
• PMID: 1962176 (Publication Type: English Abstract, Journal Article)

Chemical References

• Dinoprost

Topics

• Abortion, Induced (veterinary)
• Animals
• Dinoprost (administration & dosage, therapeutic use)
• Dog Diseases (drug therapy)
• Dogs
• Female
• Follow-Up Studies
• Pregnancy
• Pregnancy, Animal (drug effects)
• Uterine Diseases (drug therapy, veterinary)