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A case report of massive acute boric acid poisoning.

Abstract
Boric acid comes as colourless, odourless white powder and, if ingested, has potential fatal effects including metabolic acidosis, acute renal failure and shock. An 82-year-old male was brought to the emergency room 3 h after unintentional ingestion of a large amount of boric acid. Clinical course was monitored by collecting data at admittance, 12 h after admission, every 24 h for 5 days and again 1 week after admission. During the first 132 h, serum and urinary concentrations of boric acid were measured. Serum boric acid levels decreased from 1800 to 530 microg/ml after haemodialysis and from 530 to 30 microg/ml during the forced diuresis period. During dialysis, boric acid clearance averaged 235 ml/min with an extraction ratio of 70%. The overall patient's condition steadily improved over 84 h after admission. In conclusion, early treatment with forced diuresis and haemodialysis may be considered for boric acid poisoning, even if signs of renal dysfunction are not apparent, to prevent severe renal damage and its complications.
AuthorsFrancesco Corradi, Claudia Brusasco, Salvatore Palermo, Giulio Belvederi
JournalEuropean journal of emergency medicine : official journal of the European Society for Emergency Medicine (Eur J Emerg Med) Vol. 17 Issue 1 Pg. 48-51 (Feb 2010) ISSN: 1473-5695 [Electronic] England
PMID19620874 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Boric Acids
  • boric acid
Topics
  • Aged, 80 and over
  • Boric Acids (blood, poisoning)
  • Chemical Hazard Release
  • Colonoscopy (adverse effects)
  • Humans
  • Male
  • Renal Dialysis
  • Treatment Outcome

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