Abstract | BACKGROUND: OBJECTIVE: DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: A random and positive control method was adopted. Seventy-two cases of Wagner classification of grade 0 diabetic foot ulcers with blood stasis or/and kidney yang deficiency syndrome were randomly divided into treatment group and control group. There were thirty-six cases in each group. All the patients were collected from Maoming Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine. Patients received oral and written information about the clinical procedures before giving their written informed consent. The study was approved by the Ethics Committee of Maoming Hospital of Traditional Chinese Medicine. The patients in the treatment group were treated with modified Danggui Sini Decoction, and the patients in the control group were treated with cilostazol. A course of treatment was 14 days, and the patients in the two groups were treated for 3 courses. MAIN OUTCOME MEASURES: The changes of clinical symptoms, ankle-brachial index (ABI), electromyography, lower extremity arteries measured by ultrasonic Doppler, fasting blood glucose, hemoglobin A1c, fibrinogen, and plasma level of AGEs were detected in the two groups before and after treatment. The safety of modified Danggui Sini Decoction was assessed by laboratory data and adverse events. RESULTS: There were statistical differences in clinical efficacy, ABI, lower extremity arteries hemodynamics, and nerve conduction velocity between the two groups (P<0.05, P<0.01). The plasma level of AGEs after treatment was significantly decreased in the two groups, and the level of AGEs in the treatment group was lower than that in the control group (P<0.05). CONCLUSION:
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Authors | Wei-hua You, Ping Wang, Mao-qing Li, Yu Zhang, Yu-lan Peng, Feng-ling Zhang |
Journal | Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
(Zhong Xi Yi Jie He Xue Bao)
Vol. 7
Issue 7
Pg. 622-8
(Jul 2009)
ISSN: 1672-1977 [Print] China |
PMID | 19615315
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Drugs, Chinese Herbal
- Glycation End Products, Advanced
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Topics |
- Diabetic Foot
(blood, drug therapy)
- Drugs, Chinese Herbal
(therapeutic use)
- Female
- Glycation End Products, Advanced
(blood)
- Humans
- Male
- Medicine, Chinese Traditional
- Middle Aged
- Phytotherapy
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