Abstract | BACKGROUND: Previous studies have provided some evidence of a possible association between cancer and metallothioneins. Whether this relates to an exposure to carcinogenic metals remains unclear. METHODS: RESULTS: Increased expression of metallothioneins was associated with bladder tumors when compared with non-tumoral bladder tissue (OR = 9.3, 95% CI: 1.0 - 480). The concentrations of cadmium, chromium, lead and nickel in hair of cases were significantly higher than those of controls. However, as for the concentration of metals in bladder tissue, the differences were not significant. CONCLUSION:
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Authors | André F S Amaral, Teresa Cymbron, Fátima Gärtner, Manuela Lima, Armindo S Rodrigues |
Journal | BMC veterinary research
(BMC Vet Res)
Vol. 5
Pg. 24
(Jul 18 2009)
ISSN: 1746-6148 [Electronic] England |
PMID | 19615096
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Metals
- Trace Elements
- Metallothionein
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Topics |
- Adenoma
(chemistry, metabolism, veterinary)
- Animals
- Carcinoma
(chemistry, metabolism, veterinary)
- Cattle
- Cattle Diseases
(metabolism)
- Gene Expression Regulation, Neoplastic
(physiology)
- Hair
(chemistry)
- Hemangioma
(chemistry, metabolism, veterinary)
- Metallothionein
(genetics, metabolism)
- Metals
(metabolism)
- Papilloma
(chemistry, metabolism, veterinary)
- Risk Factors
- Trace Elements
(metabolism)
- Urinary Bladder Neoplasms
(chemistry, metabolism, veterinary)
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