Abstract | INTRODUCTION: METHODS: Four groups of C57/Bl6 mice received 14 Gy thoracic radiation. Mice were treated with taurine or saline supplementation by gavage. After 10 days and 14 weeks of treatment, TGF-beta1 levels were measured in serum and bronchoalveolar lavage fluid (BALF). Lung collagen content was determined using hydroxyproline analysis. RESULTS: CONCLUSION: This study presents novel findings of taurine's role in protecting from TGF-beta1-associated development of lung fibrosis after thoracic radiation.
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Authors | W B Robb, C Condron, M Moriarty, T N Walsh, D J Bouchier-Hayes |
Journal | Irish journal of medical science
(Ir J Med Sci)
Vol. 179
Issue 1
Pg. 99-105
(Mar 2010)
ISSN: 1863-4362 [Electronic] Ireland |
PMID | 19609640
(Publication Type: Journal Article)
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Chemical References |
- Transforming Growth Factor beta1
- Taurine
- Hydroxyproline
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Topics |
- Analysis of Variance
- Animals
- Bronchoalveolar Lavage Fluid
- Disease Models, Animal
- Female
- Hydroxyproline
(drug effects)
- Mice
- Pulmonary Fibrosis
(chemically induced, drug therapy, etiology)
- Radiotherapy
(adverse effects)
- Taurine
(pharmacology, therapeutic use)
- Thorax
(radiation effects)
- Time Factors
- Transforming Growth Factor beta1
(blood, drug effects)
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