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Taurine attenuates radiation-induced lung fibrosis in C57/Bl6 fibrosis prone mice.

AbstractINTRODUCTION:
The amino acid taurine has an established role in attenuating lung fibrosis secondary to bleomycin-induced injury. This study evaluates taurine's effect on TGF-beta1 expression and the development of lung fibrosis after single-dose thoracic radiotherapy.
METHODS:
Four groups of C57/Bl6 mice received 14 Gy thoracic radiation. Mice were treated with taurine or saline supplementation by gavage. After 10 days and 14 weeks of treatment, TGF-beta1 levels were measured in serum and bronchoalveolar lavage fluid (BALF). Lung collagen content was determined using hydroxyproline analysis.
RESULTS:
Ten days post radiotherapy, serum TGF-beta1 levels were significantly lower after gavage with taurine rather than saline (P = 0.033). BALF TGF-beta1 at 10 days was also significantly lower in mice treated with taurine (P = 0.031). Hydroxyproline content was also significantly lower at 14 weeks in mice treated with taurine (P = 0.020).
CONCLUSION:
This study presents novel findings of taurine's role in protecting from TGF-beta1-associated development of lung fibrosis after thoracic radiation.
AuthorsW B Robb, C Condron, M Moriarty, T N Walsh, D J Bouchier-Hayes
JournalIrish journal of medical science (Ir J Med Sci) Vol. 179 Issue 1 Pg. 99-105 (Mar 2010) ISSN: 1863-4362 [Electronic] Ireland
PMID19609640 (Publication Type: Journal Article)
Chemical References
  • Transforming Growth Factor beta1
  • Taurine
  • Hydroxyproline
Topics
  • Analysis of Variance
  • Animals
  • Bronchoalveolar Lavage Fluid
  • Disease Models, Animal
  • Female
  • Hydroxyproline (drug effects)
  • Mice
  • Pulmonary Fibrosis (chemically induced, drug therapy, etiology)
  • Radiotherapy (adverse effects)
  • Taurine (pharmacology, therapeutic use)
  • Thorax (radiation effects)
  • Time Factors
  • Transforming Growth Factor beta1 (blood, drug effects)

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