[Modification of tear film break-up time by beta blocker eyedrops without preservatives].

Abstract

Traditional beta-blocking eye drops preserved with benzalkonium chloride show an adverse effect on the precorneal tear film, which can be measured by checking the break-up-time (BUT). To decide, whether this adverse effect is caused more by the beta-blocking drug or the preservative, we tested the influence of timolol eye drops without preservative in single dose units Timosine) on the BUT in a prospective, open study. These eyedrops caused no significant shortening of the BUT in persons, which where untreated before. Patients using preserved beta-blocking eye drops and having irritations of their eyes showed significant prolongation of the BUT after changing the therapy to Timosine. Preservative-free beta-blocking eye drops are a real improvement in the therapy of glaucoma patients with irritated eyes.

• Authors: R Marquardt, T Schubert
• Journal: Klinische Monatsblatter fur Augenheilkunde (Klin Monbl Augenheilkd) Vol. 199 Issue 2 Pg. 75-8 (Aug 1991) ISSN: 0023-2165 [Print] Germany
• Vernacular Title: Beeinflussung der Tränenfilmaufreisszeit (BUT) durch Betablocker-Augentropfen ohne Konservierungsstoffe.
• PMID: 1960936 (Publication Type: English Abstract, Journal Article)

Chemical References

• Ophthalmic Solutions
• Preservatives, Pharmaceutical
• Timolol

Topics

• Glaucoma (drug therapy, physiopathology)
• Humans
• Ocular Hypertension (drug therapy, physiopathology)
• Ophthalmic Solutions
• Preservatives, Pharmaceutical (adverse effects)
• Tears (drug effects, physiology)
• Timolol (administration & dosage, adverse effects)