Inflammatory BCG adenitis associated with immune reconstitution following allogeneic haematopoietic stem cell transplant in infancy.

Abstract

We describe four cases of a localized, granulomatous reaction to BCG including ipsilateral painful, suppurative lymphadenopathy associated with donor immune reconstitution following allogeneic haematopoietic stem cell transplant performed in infancy and preceded by uneventful, routine BCG immunisation. The management of the inflammatory disease in these cases with surgery, antimycobacterial chemotherapy and steroids, is discussed.

• Authors: E Searle, H Patel, F J Vilar, M Gharib, A J Turner, G Batra, R F Wynn
• Journal: Pediatric blood & cancer (Pediatr Blood Cancer) Vol. 54 Issue 1 Pg. 166-9 (Jan 2010) ISSN: 1545-5017 [Electronic] United States
• PMID: 19606456 (Publication Type: Case Reports, Journal Article)
• Copyright: Copyright 2009 Wiley-Liss, Inc.

Chemical References

• BCG Vaccine

Topics

• BCG Vaccine (therapeutic use)
• Female
• Hematopoietic Stem Cell Transplantation
• Humans
• Infant
• Infant, Newborn
• Inflammation (immunology)
• Lymphadenitis (immunology, therapy)
• Male
• Transplantation, Homologous