HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Neuroaspergillosis in an immunocompetent patient successfully treated with voriconazole and a corticosteroid.

Abstract
Aspergillosis of the central nervous system (CNS) is an uncommon infection, mainly occurring in immunocompromised patients. We report a case of nasocerebral aspergillosis in an immunocompetent patient successfully treated with voriconazole and a corticosteroid. Magnetic resonance imaging (MRI) showed contrast enhancement surrounding the brainstem and cerebellum with intramedullary pontine and cerebellar T2-hyperintense lesions. The patient's symptoms and MRI abnormalities improved after voriconazole and corticosteroid treatment; however, discontinuation of the corticosteroid caused a worsening of the T2-hyperintense lesions, whereas resuming it resulted in its improvement. This suggested that these T2-hyperintense lesions may be due to secondary inflammation caused by aspergillosis and not the aspergillosis itself. We conclude that treatment with a combination of voriconazole and a corticosteroid appears to be effective for the treatment of some patients with CNS aspergillosis.
AuthorsAkiyuki Hiraga, Akiyuki Uzawa, Mariko Shibuya, Tsutomu Numata, Shigeko Sunami, Ikuo Kamitsukasa
JournalInternal medicine (Tokyo, Japan) (Intern Med) Vol. 48 Issue 14 Pg. 1225-9 ( 2009) ISSN: 1349-7235 [Electronic] Japan
PMID19602790 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antifungal Agents
  • Pyrimidines
  • Triazoles
  • Voriconazole
Topics
  • Aged
  • Antifungal Agents (therapeutic use)
  • Brain Diseases (drug therapy, microbiology)
  • Humans
  • Immunocompetence
  • Male
  • Neuroaspergillosis (drug therapy)
  • Pyrimidines (therapeutic use)
  • Remission Induction
  • Triazoles (therapeutic use)
  • Voriconazole

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: