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Prevention of surgery in children with adenoidal hypertrophy treated with intranasal flunisolide: a 12-month follow-up.

Abstract
Adenoidal hypertrophy (AH) represents one of the most frequent indications for surgery in children. Recently, treatment with intranasal corticosteroids has been suggested to decrease the size of AH. The aim of the study is to evaluate the long-term effect of intranasal flunisolide on AH during a 12-month follow-up. One hundred seventy-eight children with a grade III or IV AH at baseline endoscopic examination were enrolled in this randomised and controlled study. Children were treated with intranasal flunisolide or isotonic saline solution for 8 weeks. Subsequent assessment, including history and fiberoptic endoscopy, was made at 8 weeks, and 6 and 12 months after treatment suspension. Flunisolide treatment was initially associated with significant (p<0.01) reduction of the degree of AH. However, during follow-up all but one of the non-allergic children relapsed, whereas most allergic children maintained AH size reduction (p<0.05). No clinically important adverse events were reported. In conclusion, this preliminary study demonstrates that an 8-week treatment with intranasal flunisolide is significantly associated with reduction of AH, however, the adenoidectomy avoidance was warranted only for allergic children.
AuthorsA Varricchio, G Tortoriello, M Capasso, A De Lucia, P Marchisio, A M Varricchio, N Mansi, L Giordano, G Liberatore, M Di Gioacchino, G Ciprandi
JournalJournal of biological regulators and homeostatic agents (J Biol Regul Homeost Agents) 2009 Apr-Jun Vol. 23 Issue 2 Pg. 95-101 ISSN: 0393-974X [Print] Italy
PMID19589290 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References
  • Glucocorticoids
  • Fluocinolone Acetonide
  • flunisolide
Topics
  • Adenoidectomy
  • Adenoids (drug effects, pathology, surgery)
  • Administration, Intranasal
  • Child
  • Child, Preschool
  • Female
  • Fluocinolone Acetonide (administration & dosage, analogs & derivatives)
  • Follow-Up Studies
  • Glucocorticoids (administration & dosage)
  • Humans
  • Hypertrophy (complications, drug therapy, surgery)
  • Male
  • Nasal Obstruction (drug therapy, etiology, surgery)
  • Single-Blind Method
  • Time Factors

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