Abstract | BACKGROUND: Although there have been some epidemiological studies on the effects of diet and nutritional status on cervical carcinogenesis, evidence for a protective effect of antioxidant micronutrients against cervical neoplasia is insufficient. The relationship between serum antioxidant micronutrients and sociodemographic factors and the risk of cervical neoplasia was investigated in this multi-center, case-control study. METHODS: RESULTS:
Cervical cancer was found to be associated with older age, increased body mass index, and lower socioeconomic status as measured by education level and income. The mean serum concentrations of beta-carotene, lycopene, zeaxanthin plus lutein, retinol, alpha-tocopherol, and gamma-tocopherol of cervical cancer patients were significantly lower than those of control subjects. Odds ratio adjusted for age, smoking status, alcohol consumption, and human papillomavirus infection status revealed a significant gradient of decreasing risk of CIN 1, CIN 2/3, and cervical cancer with increasing serum concentrations of most antioxidant micronutrients. CONCLUSIONS:
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Authors | Hanbyoul Cho, Mi Kyung Kim, Jae Kwan Lee, Sung Kyong Son, Kwang-Beom Lee, Jong-Min Lee, Jung Pil Lee, Soo Young Hur, Jae-Hoon Kim |
Journal | Clinical chemistry and laboratory medicine
(Clin Chem Lab Med)
Vol. 47
Issue 8
Pg. 1005-12
( 2009)
ISSN: 1437-4331 [Electronic] Germany |
PMID | 19589102
(Publication Type: Journal Article, Multicenter Study)
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Chemical References |
- Antioxidants
- Micronutrients
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Topics |
- Adult
- Antioxidants
(analysis)
- Case-Control Studies
- Female
- Humans
- Korea
(epidemiology)
- Micronutrients
(blood)
- Middle Aged
- Risk Factors
- Socioeconomic Factors
- Uterine Cervical Neoplasms
(blood, epidemiology)
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