Chronic inflammatory demyelinating polyneuropathy accompanied by chronic myelomonocytic leukemia: possible pathogenesis of autoimmunity in myelodysplastic syndrome.

Abstract

Paraneoplastic neuropathies have rarely been reported in patients with hematological malignancies. We report herein the case of a 65-year-old Japanese woman with chronic myelomonocytic leukemia (CMML) accompanying chronic inflammatory demyelinating polyneuropathy (CIDP). She had been diagnosed with refractory anemia and subsequently developed CMML with cytogenetic abnormalities including t(3;8)(q26;q24). While regenerating bone marrow following induction chemotherapy, she complained of numbness in the lower legs and then became unable to walk. Clinical and electrophysiological features were consistent with CIDP. Intravenous immunoglobulin treatment was insufficient, although corticosteroids reduced neurological symptoms. This case suggests CIDP as one of the autoimmune phenomena associated with myelodysplastic syndrome and immunosuppressive treatment represents an effective therapy.

• Authors: Atsushi Isoda, Atsushi Sakurai, Yoshiyuki Ogawa, Yuri Miyazawa, Akio Saito, Morio Matsumoto, Morio Sawamura
• Journal: International journal of hematology (Int J Hematol) Vol. 90 Issue 2 Pg. 239-242 (Sep 2009) ISSN: 1865-3774 [Electronic] Japan
• PMID: 19588217 (Publication Type: Case Reports, Journal Article)

Topics

• Asian People
• Autoimmune Diseases (complications, immunology)
• Bone Marrow (pathology)
• Female
• Humans
• Leukemia, Myelomonocytic, Chronic (complications, immunology, pathology)
• Middle Aged
• Myelodysplastic Syndromes (immunology, pathology)
• Neural Conduction
• Polyradiculoneuropathy, Chronic Inflammatory Demyelinating (complications, immunology)