Abstract | BACKGROUND/PURPOSE: METHODS: This randomized, double-blind, controlled study enrolled 174 female patients who were undergoing total abdominal hysterectomy, myomectomy, or ovarian tumor excision. In the control group, the PCA formula was 1 mg/mL pure morphine. In the study group, the PCA formula was 1 mg/mL morphine and 10 microg/mL nalbuphine (1:100). Numerical rating score, PCA requirement, nausea, vomiting, use of antiemetics, pruritus, use of antipruritics, and opioid-related adverse events were investigated at 1, 2, 4, and 24 hours postoperatively. RESULTS: One hundred and sixty-nine patients completed the study: 86 in the control group and 83 in the study group. The incidence of nausea was lower in the study group (41%) than in the control group (65%). The incidence of vomiting, use of antiemetics, pruritus, and use of antipruritics did not differ between the two groups. The numerical rating pain score and PCA requirements were not significantly different between the two groups. CONCLUSION:
|
Authors | Yu-Chang Yeh, Tzu-Fu Lin, Hung-Chi Chang, Wing-Sum Chan, Yong-Ping Wang, Chen-Jung Lin, Wei-Zen Sun |
Journal | Journal of the Formosan Medical Association = Taiwan yi zhi
(J Formos Med Assoc)
Vol. 108
Issue 7
Pg. 548-53
(Jul 2009)
ISSN: 0929-6646 [Print] Singapore |
PMID | 19586828
(Publication Type: Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Analgesics, Opioid
- Morphine
- Nalbuphine
|
Topics |
- Adolescent
- Adult
- Aged
- Analgesia, Patient-Controlled
- Analgesics, Opioid
(administration & dosage)
- Double-Blind Method
- Female
- Humans
- Middle Aged
- Morphine
(administration & dosage, adverse effects)
- Nalbuphine
(administration & dosage, adverse effects)
- Pain, Postoperative
(drug therapy)
|