Abstract | BACKGROUND: METHODS: We used the case control method to test for genetic association with variants at these loci in a sample of 431 patients with schizophrenia, 303 patients with bipolar disorder and 442 ancestrally matched supernormal controls all selected from the UK population. RESULTS: Ten SNPs spanning the DAOA locus were genotyped in these samples. In addition three SNPs were genotyped at the DAO locus in the schizophrenia sample. Allelic association was detected between the marker rs3918342 (M23), 3' to the DAOA gene and both schizophrenia (chi2 = 5.824 p = 0.016) and bipolar disorder (chi2 = 4.293 p = 0.038). A trend towards association with schizophrenia was observed for two other DAOA markers rs3916967 (M14, chi2 = 3.675 p = 0.055) and rs1421292 (M24; chi2 = 3.499 p = 0.062). A test of association between a three marker haplotype comprising of the SNPs rs778293 (M22), rs3918342 (M23) and rs1421292 (M24) and schizophrenia gave a global empirical significance of p = 0.015. No evidence was found to confirm the association of genetic markers at the DAO gene with schizophrenia. CONCLUSION:
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Authors | Nicholas J Bass, Susmita R Datta, Andrew McQuillin, Vinay Puri, Khalid Choudhury, Srinivasa Thirumalai, Jacob Lawrence, Digby Quested, Jonathan Pimm, David Curtis, Hugh Md Gurling |
Journal | Behavioral and brain functions : BBF
(Behav Brain Funct)
Vol. 5
Pg. 28
(Jul 08 2009)
ISSN: 1744-9081 [Electronic] England |
PMID | 19586533
(Publication Type: Journal Article)
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