[Successful treatment of treatment-resistant opioid-induced constipation in a patient with incomplete paraplegia with methylnaltrexone].

Abstract

We observed a patient with incomplete, cervical paraplegia and opioid-induced constipation who developed a resistance to laxatives after 15 years of treatment. The constipation-induced reduction in the patient's quality of life was improved using 12 mg methylnaltrexone, a peripheral mu-opioid receptor antagonist, administered subcutaneously twice a week.

• Authors: E A Lux
• Journal: Schmerz (Berlin, Germany) (Schmerz) Vol. 23 Issue 5 Pg. 523-4 (Oct 2009) ISSN: 1432-2129 [Electronic] Germany
• Vernacular Title: Behandlung einer therapieresistenten, opioidbedingten Obstipation bei inkomplettem Querschnittssyndrom mit Methylnaltrexon.
• PMID: 19585156 (Publication Type: Case Reports, Journal Article)

Chemical References

• Narcotic Antagonists
• Narcotics
• Quaternary Ammonium Compounds
• methylnaltrexone
• Naltrexone

Topics

• Aged
• Cervical Vertebrae (surgery)
• Constipation (chemically induced, drug therapy)
• Fecal Impaction (chemically induced, drug therapy)
• Humans
• Injections, Subcutaneous
• Male
• Naltrexone (adverse effects, analogs & derivatives, therapeutic use)
• Narcotic Antagonists (adverse effects, therapeutic use)
• Narcotics (adverse effects, therapeutic use)
• Paraplegia (complications)
• Postoperative Complications (drug therapy)
• Quaternary Ammonium Compounds (adverse effects, therapeutic use)
• Spinal Cord Compression (surgery)