Abstract | OBJECTIVE: CLINICAL PRESENTATION: The patient presented with a progressive left-sided weakness 62 years after initial surgery for a right parietal cerebral abscess, which included the instillation of Thorotrast into the abscess cavity. Computed tomography showed a right parietal tumor. INTERVENTION: An explorative craniotomy showed an intrinsic, infiltrating, very vascular tumor with surrounding calcification. The tumor appeared to arise from a benign cavernous vasoformative lesion intimately associated with a Thorotrast-type granuloma. The patient declined further surgery or radiotherapy. CONCLUSION: The histology, confirmation of radioactivity of the material obtained from within the tumor, and latency period of presentation provide compelling support for tumor induction by the Thorotrast. Primary lesions of the central nervous system associated with Thorotrast are very rarely reported, despite its extensive use in cerebral angiography and management of brain abscess between 1930 and 1960.
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Authors | Gopalakrishnan Balamurali, Daniel G du Plessis, Moses Wengoy, Nicholas Bryan, Amit Herwadkar, Peter L Richardson |
Journal | Neurosurgery
(Neurosurgery)
Vol. 65
Issue 1
Pg. E210-1; discussion E211
(Jul 2009)
ISSN: 1524-4040 [Electronic] United States |
PMID | 19574803
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Carcinogens
- Thorium Dioxide
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Topics |
- Aged
- Brain Neoplasms
(chemically induced, diagnosis, surgery)
- Carcinogens
(pharmacology)
- Cerebral Angiography
- Cerebral Cortex
(pathology, surgery)
- Hemangiosarcoma
(chemically induced, diagnosis, surgery)
- Humans
- Male
- Thorium Dioxide
(pharmacology)
- Tomography, X-Ray Computed
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