Abstract |
Pseudomembranous colitis (PMC) is known to develop after antibiotic treatment, but is rarely associated with antituberculosis (anti-TB) agents. We report a 28-year-old woman without underlying diseases developing PMC after 126 days of anti-TB treatment. Severe diarrhea and abdominal cramping pain were experienced. Colonoscopic biopsy proved the diagnosis of PMC. Her symptoms improved after discontinuing the anti-TB agents but recurred shortly after challenging with rifampin and isoniazid. Metronidazole administration and replacement of rifampin with levofloxacin successfully cured the PMC. Our report supports the notion that rifampin can induce PMC.
|
Authors | Tun-Chieh Chen, Po-Liang Lu, Wei-Ru Lin, Chun-Yu Lin, Jeng-Yih Wu, Yen-Hsu Chen |
Journal | The American journal of the medical sciences
(Am J Med Sci)
Vol. 338
Issue 2
Pg. 156-8
(Aug 2009)
ISSN: 0002-9629 [Print] United States |
PMID | 19561451
(Publication Type: Case Reports, Journal Article)
|
Chemical References |
- Antitubercular Agents
- Rifampin
|
Topics |
- Adult
- Antitubercular Agents
(adverse effects)
- Clostridioides difficile
(drug effects)
- Enterocolitis, Pseudomembranous
(chemically induced, pathology)
- Female
- Humans
- Rifampin
(adverse effects)
|