Calretinin: diagnostic utility in the female genital tract.

Abstract

The utility of calretinin was first described in the diagnosis of mesothelioma. In the female genital tract, calretinin was initially reported in Wolffian remnants and related lesions and later used in the diagnosis of sex cord stromal tumors of the ovary, endometrial stromal tumors with sex cord-like differentiation, and uterine tumors resembling sex cord tumors of the ovary. This review discusses calretinin expression in normal tissues of the female genital tract and highlights its potential utility in the diagnosis of these subsets of neoplasms with emphasis to tumors that may constitute a problem in their differential diagnosis. In particular, the limited utility of calretinin in the diagnosis of sex cord stromal tumors of the ovary, in the differential diagnosis between mesothelioma and serous tumors involving the ovary and/or peritoneum, and in the differential diagnosis between Wolffian lesions and endometrial carcinoma are addressed.

• Authors: Raquel Portugal, Esther Oliva
• Journal: Advances in anatomic pathology (Adv Anat Pathol) Vol. 16 Issue 2 Pg. 118-24 (Mar 2009) ISSN: 1533-4031 [Electronic] United States
• PMID: 19550372 (Publication Type: Journal Article, Review)

Chemical References

• Biomarkers, Tumor
• CALB2 protein, human
• Calbindin 2
• S100 Calcium Binding Protein G

Topics

• Biomarkers, Tumor (metabolism)
• Calbindin 2
• Diagnosis, Differential
• Female
• Genital Neoplasms, Female (diagnosis, metabolism)
• Humans
• Mesothelioma (diagnosis, metabolism)
• Neoplasms, Cystic, Mucinous, and Serous (diagnosis, metabolism)
• S100 Calcium Binding Protein G (metabolism)
• Sex Cord-Gonadal Stromal Tumors (diagnosis, metabolism)