Increased type 3 iodothyronine deiodinase activity in a regrown hepatic hemangioma with consumptive hypothyroidism.

Abstract

INTRODUCTION:

Infantile hepatic hemangioma with consumptive hypothyroidism is a rare condition.

CASE REPORT:

A 4-month-old girl presented with diffuse hepatic hemangiomas during treatment of congenital hypothyroidism. Serum reverse triiodothyronine was elevated, and her hypothyroidism improved concomitant with involution of the hemangioma following prednisolone and interferon-alpha administration. At 20 months of age, 7 months after discontinuing prednisolone and interferon-alpha, a focal hemangioma regrew from one of the previous lesions and was surgically resected. The expression and activity of type 3 iodothyronine deiodinase (D3) were elevated in the resected tumor tissue compared with placenta.

DISCUSSION:

Here, we describe a patient with consumptive hypothyroidism and diffuse infantile hepatic hemangiomas, one of which regrew after involution following pharmacotherapy. The etiology of elevated D3 activity is also discussed.

CONCLUSION:

It is important to identify infantile hepatic hemangioma in patients with hypothyroidism refractory to hormone replacement therapy, who have low free triiodothyronine despite high thyrotropin and normal free thyroxine levels, and long-term follow-up will be needed for these patients.

• Authors: Kazuhiko Bessho, Yuri Etani, Hiroaki Ichimori, Yoko Miyoshi, Noriyuki Namba, Akihiro Yoneda, Takaharu Ooue, Tsuyoshi Chihara, Eiichi Morii, Tomoyuki Aoki, Masami Murakami, Sotaro Mushiake, Keiichi Ozono
• Journal: European journal of pediatrics (Eur J Pediatr) Vol. 169 Issue 2 Pg. 215-21 (Feb 2010) ISSN: 1432-1076 [Electronic] Germany
• PMID: 19548001 (Publication Type: Case Reports, Journal Article)

Chemical References

• Biomarkers, Tumor
• RNA, Neoplasm
• iodothyronine deiodinase type III
• Iodide Peroxidase

Topics

• Biomarkers, Tumor (genetics, metabolism)
• Diagnosis, Differential
• Female
• Follow-Up Studies
• Gene Expression Regulation, Neoplastic
• Hemangioma (complications, diagnosis, enzymology)
• Humans
• Hypothyroidism (complications, enzymology)
• Infant
• Iodide Peroxidase (genetics, metabolism)
• Liver (metabolism, pathology)
• Liver Neoplasms (complications, diagnosis, enzymology)
• Magnetic Resonance Imaging
• Polymerase Chain Reaction
• RNA, Neoplasm (genetics)
• Time Factors