[A case of recurrent gastrointestinal stromal tumor of the stomach with complete response to imatinib mesilate].

Abstract

We report a patient who long had a complete response by chemotherapy with imatinib mesilate(IM)for locally recurrent gastrointestinal stromal tumor(GIST)of the stomach. On July 2000, a 58-year-old woman was pointed out to have anemia in the course of surveillance for malignant melanoma of skin. Endoscopic examination revealed continuous bleeding from a submucosal tumor with ulceration on the posterior wall of the stomach. After endoscopic homeostasis failed, emergency laparotomy was performed and a biopsy was also done. The diagnosis made was GIST from immunohistological findings of positive c-kit, positive CD34, negative HMB45, and negative S100. After diagnosis, total gastrectomy, distal pancreatectomy, and splenectomy were performed. On September 2003, a local recurrence was recognized, and then chemotherapy by 400 mg IM daily was started. After beginning with a dose of IM 400 mg daily, the reduction of the tumor was monitored. The IM dose then had to be reduced to 300 mg daily. Because of the adverse side effects of IM, systemic edema and body weight increased. After reduction of IM, the adverse reactions resolved promptly, and a complete response of the primary tumor has been maintained for 4 years 3 months.

• Authors: Toru Aoyama, Hiroyuki Saeki, Jouji Samejima, Keita Fujii, Yoshihiro Ishikawa, Masakazu Kawamoto, Jun Fujisawa, Hiroshi Matsukawa, Yasushi Rino, Munetaka Masuda
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 36 Issue 6 Pg. 975-8 (Jun 2009) ISSN: 0385-0684 [Print] Japan
• PMID: 19542718 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Benzamides
• Piperazines
• Pyrimidines
• Imatinib Mesylate

Topics

• Antineoplastic Agents (administration & dosage, adverse effects, therapeutic use)
• Benzamides
• Female
• Gastrointestinal Stromal Tumors (drug therapy)
• Humans
• Imatinib Mesylate
• Middle Aged
• Neoplasm Recurrence, Local
• Piperazines (administration & dosage, adverse effects, therapeutic use)
• Pyrimidines (administration & dosage, adverse effects, therapeutic use)
• Remission Induction
• Stomach Neoplasms (drug therapy)