Dancing Eye Syndrome associated with spontaneous recovery and normal neurodevelopment.

Abstract

Five patients with spontaneously recovering Dancing Eye Syndrome/Opsoclonus Myoclonus Syndrome are described. Age at presentation ranged from 4 to 19 months. Four had symptoms of fever and a coryzal illness within days to a few weeks prior to the onset. One of the 4 also had varicella zoster 4 weeks before presentation. All had opsoclonus, myoclonus/ataxia and irritability. Associated infective agents identified were Coxsackie virus and rotavirus. Spontaneous improvement of symptoms started within 9 days of presentation and total duration of illness ranged from 10 to 24 days. Developmental progress at follow-up was normal in all cases. A range of immunomodulatory therapies have been advocated for the treatment of Dancing Eye Syndrome/Opsoclonus Myoclonus Syndrome. However, in some children, early spontaneous recovery may occur, an observation which should be borne in mind when designing therapeutic trials in this condition.

• Authors: K Ki Pang, Bryan J Lynch, John P Osborne, Michael G Pike
• Journal: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society (Eur J Paediatr Neurol) Vol. 14 Issue 2 Pg. 178-81 (Mar 2010) ISSN: 1532-2130 [Electronic] England
• PMID: 19541513 (Publication Type: Case Reports, Journal Article)
• Copyright: 2009 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved.

Chemical References

• Anti-Infective Agents
• Immunologic Factors

Topics

• Anti-Infective Agents (therapeutic use)
• Ataxia (complications)
• Brain (physiology)
• Child Development (physiology)
• Coxsackievirus Infections (complications, drug therapy, virology)
• Female
• Humans
• Immunologic Factors (therapeutic use)
• Infant
• Infant, Newborn
• Male
• Opsoclonus-Myoclonus Syndrome (complications, diagnosis, drug therapy)
• Recovery of Function
• Remission, Spontaneous
• Rotavirus Infections (complications, drug therapy, virology)