Sertaconazole nitrate cream 2% for the treatment of tinea pedis.

Abstract

Tinea pedis, both in its acute and chronic phase, is a common skin condition that often is overlooked but can lead to onychomycosis and acute bacterial cellulitis if left untreated. Therefore, aggressive treatment with a topical antifungal agent is warranted. Sertaconazole nitrate cream 2% is a newer imidazole agent that possesses both fungicidal and fungistatic properties to eradicate existing infections. In addition to antifungal properties, it exhibits anti-inflammatory and antipruritic effects. Controlled clinical trials have confirmed its safety, tolerability, and efficacy in participants with tinea pedis. We report 2 patients with chronic tinea pedis of many years' duration and demonstrate the usefulness of sertaconazole nitrate cream 2% in the clinical setting. Tinea pedis was confirmed by results of a potassium hydroxide preparation. Both patients experienced marked improvement by the second week of twice-daily treatment with sertaconazole nitrate cream 2%. Clinical cure was achieved in both patients. These findings suggest that sertaconazole nitrate cream 2% is an effective option for the treatment of tinea pedis.

• Authors: Bret M Ribotsky
• Journal: Cutis (Cutis) Vol. 83 Issue 5 Pg. 274-7 (May 2009) ISSN: 0011-4162 [Print] United States
• PMID: 19537285 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents
• Antifungal Agents
• Imidazoles
• Ointments
• Thiophenes
• sertaconazole

Topics

• Administration, Topical
• Aged
• Anti-Inflammatory Agents (administration & dosage)
• Antifungal Agents (administration & dosage)
• Female
• Humans
• Imidazoles (administration & dosage)
• Male
• Ointments
• Thiophenes (administration & dosage)
• Tinea Pedis (drug therapy)
• Treatment Outcome