Sacroiliitis and severe disability due to isotretinoin therapy.

Abstract	We report a case of acute sacroiliitis with severe disability after only 3 weeks of isotretinoin therapy with graduate reduction of pain, limitation and muscle incompetence after discontinuation of the drug and ACTH-depo injection and Ethodolac therapy. Naranjo probability scale indicated a probable relationship between isotretinoin therapy and bilateral sacroiliitis. We discussed possible mechanisms of sacroiliitis and disability due to isotretinoin treatment.
Authors	Alexander P Rozin, Olga Kagna, Yizhak Shiller
Journal	Rheumatology international (Rheumatol Int) Vol. 30 Issue 7 Pg. 985-6 (May 2010) ISSN: 1437-160X [Electronic] Germany
PMID	19533139 (Publication Type: Case Reports, Journal Article)
Chemical References	Anti-Inflammatory Agents, Non-Steroidal Dermatologic Agents Etodolac Adrenocorticotropic Hormone Isotretinoin
Topics	Acne Vulgaris (drug therapy) Adrenocorticotropic Hormone (therapeutic use) Adult Anti-Inflammatory Agents, Non-Steroidal (therapeutic use) Arthralgia (chemically induced, pathology, physiopathology) Arthritis (chemically induced, pathology, physiopathology) Dermatologic Agents (adverse effects) Disability Evaluation Edema (chemically induced, pathology) Etodolac (therapeutic use) Humans Iatrogenic Disease (prevention & control) Isotretinoin (adverse effects) Low Back Pain (chemically induced, pathology, physiopathology) Magnetic Resonance Imaging Male Muscle Weakness (etiology, physiopathology) Radiography Sacroiliac Joint (diagnostic imaging, drug effects, pathology) Treatment Outcome Whole Body Imaging (methods)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!