A COX-2 inhibitor reduces muscle soreness, but does not influence recovery and adaptation after eccentric exercise.

Abstract

The aim of this study was to investigate the effect of a cyclooxygenase (COX)-2 inhibitor on the recovery of muscle function, inflammation, regeneration after, and adaptation to, unaccustomed eccentric exercise. Thirty-three young males and females participated in a double-blind, placebo-controlled experiment. Seventy unilateral, voluntary, maximal eccentric actions with the elbow flexors were performed twice (bouts 1 and 2) with the same arm, separated by 3 weeks. The test group participants were administered 400 mg/day of celecoxib for 9 days after bout 1. After both bouts 1 and 2, concentric and isometric force-generating capacity was immediately reduced (approximately 40-50%), followed by the later appearance of muscle soreness and increased serum creatine kinase levels. Radiolabelled autologous leukocytes (detected by scintigraphy) and monocytes/macrophages (histology) accumulated in the exercised muscles, simultaneously with increased satellite cell activity. These responses were reduced and recovery was faster after bout 2 than 1, demonstrating a repeated-bout effect. No differences between the celecoxib and placebo groups were detected, except for muscle soreness, which was attenuated by celecoxib. In summary, celecoxib, a COX-2 inhibitor, did not detectably affect recovery of muscle function or markers of inflammation and regeneration after unaccustomed eccentric exercise, nor did the drug influence the repeated-bout effect. However, it alleviated muscle soreness.

• Authors: G Paulsen, I M Egner, M Drange, H Langberg, H B Benestad, J G Fjeld, J Hallén, T Raastad
• Journal: Scandinavian journal of medicine & science in sports (Scand J Med Sci Sports) Vol. 20 Issue 1 Pg. e195-207 (Feb 2010) ISSN: 1600-0838 [Electronic] Denmark
• PMID: 19522751 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Cyclooxygenase 2 Inhibitors
• Pyrazoles
• Sulfonamides
• Celecoxib
• Dinoprostone

Topics

• Adaptation, Physiological (drug effects)
• Adult
• Arm (physiology)
• Celecoxib
• Cyclooxygenase 2 Inhibitors (pharmacology)
• Dinoprostone (metabolism)
• Double-Blind Method
• Exercise (physiology)
• Female
• Humans
• Immunohistochemistry
• Isometric Contraction (drug effects)
• Leukocytes (metabolism)
• Male
• Microdialysis
• Muscle Contraction (drug effects, physiology)
• Muscle, Skeletal (diagnostic imaging, drug effects, metabolism)
• Pain (physiopathology, prevention & control)
• Pyrazoles (pharmacology)
• Radionuclide Imaging
• Recovery of Function (drug effects, physiology)
• Satellite Cells, Skeletal Muscle (metabolism)
• Sulfonamides (pharmacology)
• Young Adult