[Alzheimer's disease and methylenetetrahydrofolate reductase gene polymorphisms: a potential nutrigenomic approach for Mexico].

Abstract

The establishment of medical genomics in Mexico offers the possibility to study in a more comprehensive manner the etiological factors of different diseases, providing a global view of the interaction between the genome and the environment. Nutrition is recognized as a significant determinant in several diseases, yet its interaction with polymorphisms, and in general with the genome, has not been properly addressed Mexico has a high prevalence of polymorphisms of the methylenetetrahydrofolate reductase gene, and in both clinical and basic studies this has been associated with an increased susceptibility of developing Alzheimer's disease. We propose a potential nutrigenomic approach for the study of Alzheimer disease in Mexico.

• Authors: Jorge I Castillo-Quan, Julia M Pérez-Osorio
• Journal: Gaceta medica de Mexico (Gac Med Mex) 2009 Mar-Apr Vol. 145 Issue 2 Pg. 147-50 ISSN: 0016-3813 [Print] Mexico
• Vernacular Title: La enfermedad de Alzheimer y los polimorfismos del gen metilenotetrahidrofolato reductasa: una potencial aproximación nutrigenómica en México.
• PMID: 19518022 (Publication Type: English Abstract, Journal Article)

Chemical References

• Methylenetetrahydrofolate Reductase (NADPH2)

Topics

• Alzheimer Disease (enzymology, genetics)
• Humans
• Methylenetetrahydrofolate Reductase (NADPH2) (genetics)
• Mexico
• Nutrigenomics
• Polymorphism, Genetic