Effects of quercetin and EGCG on mitochondrial biogenesis and immunity.

Abstract

PURPOSE:

To test the influence of 1000 mg of quercetin (Q) with or without 120 mg of epigallocatechin 3-gallate (EGCG), 400 mg of isoquercetin, and 400 mg of eicosapentaenoic acid and docosahexaenoic acid (Q-EGCG) on exercise performance, muscle mitochondrial biogenesis, and changes in measures of immunity and inflammation before and after a 3-d period of heavy exertion.

METHODS:

Trained cyclists (N = 39) were randomized to placebo (P), Q, or Q-EGCG and ingested supplements in a double-blinded fashion for 2 wk before, during, and 1 wk after a 3-d period in which subjects cycled for 3 h x d(-1) at approximately 57% Wmax. Blood, saliva, and muscle biopsy samples were collected before and after 2 wk of supplementation and immediately after the exercise bout on the third day. Blood and saliva samples were also collected 14 h after exercise.

RESULTS:

Two-week supplementation resulted in a significant increase in plasma quercetin for Q and Q-EGCG and granulocyte oxidative burst activity (GOBA) in Q-EGCG. Immediately after the third exercise bout, significant decreases for C-reactive protein (CRP), and plasma interleukin 6 (IL-6) and interleukin 10 (IL-10) were measured in Q-EGCG compared with P. Granulocyte colony-stimulating factor and CRP were reduced in Q-EGCG 14 h after exercise. No group differences were measured in muscle messenger RNA expression for peroxisome proliferator-activated receptor gamma coactivator alpha, citrate synthase, or cytochrome c.

CONCLUSIONS:

Two-week supplementation with Q-EGCG was effective in augmenting GOBA andin countering inflammation after 3 d of heavy exertion in trained cyclists.

• Authors: David C Nieman, Dru A Henson, Kendra R Maxwell, Ashley S Williams, Steven R McAnulty, Fuxia Jin, R Andrew Shanely, Thomas C Lines
• Journal: Medicine and science in sports and exercise (Med Sci Sports Exerc) Vol. 41 Issue 7 Pg. 1467-75 (Jul 2009) ISSN: 1530-0315 [Electronic] United States
• PMID: 19516153 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Antioxidants
• Fatty Acids, Unsaturated
• Interleukin-6
• PPAR gamma
• RNA, Messenger
• Interleukin-10
• Granulocyte Colony-Stimulating Factor
• Docosahexaenoic Acids
• Catechin
• C-Reactive Protein
• Quercetin
• Eicosapentaenoic Acid
• epigallocatechin gallate

Topics

• Adult
• Antioxidants (pharmacology)
• C-Reactive Protein
• Catechin (analogs & derivatives, pharmacology)
• Dietary Supplements
• Docosahexaenoic Acids (pharmacology)
• Double-Blind Method
• Eicosapentaenoic Acid
• Fatty Acids, Unsaturated (blood, pharmacology)
• Female
• Granulocyte Colony-Stimulating Factor (blood)
• Humans
• Interleukin-10 (blood)
• Interleukin-6 (blood)
• Male
• Mitochondria (drug effects)
• Oxidative Stress
• PPAR gamma (drug effects)
• Quercetin (blood, pharmacology)
• RNA, Messenger