Improvement in visual acuity in chronic aphakic and pseudophakic cystoid macular edema after treatment with topical 0.5% ketorolac tromethamine.

Abstract

Ketorolac tromethamine 0.5% ophthalmic solution treatment was compared to placebo treatment in 120 patients with chronic aphakic or pseudophakic cystoid macular edema (six-month or more duration of distance visual acuity of 20/40 or less and angiographic evidence of cystoid changes) during a four- to five-month double-masked, multicenter study in which patients were randomly assigned. A statistically significant improvement in distance visual acuity (two lines or more) was observed in the ketorolac-treated group as compared to the placebo-treated group after 30 days (P = .038), 60 days (P = .017), and 90 days (P = .008) of treatment. This improvement in visual acuity remained statistically significant one month after cessation of treatment (P = .001). Nine ketorolac-treated patients and two placebo-treated patients demonstrated a decrease in visual acuity one month after treatment was discontinued. Seven of the nine ketorolac-treated patients experienced an improvement in visual acuity after retreatment as compared to none of the placebo-treated patients. This study offers evidence for a more optimistic outlook in the medical treatment of chronic aphakic and pseudophakic cystoid macular edema.

• Authors: A J Flach, L M Jampol, D Weinberg, M C Kraff, L A Yannuzzi, R V Campo, A C Neumann, H P Cupples, W H Lefler, J S Pulido
• Journal: American journal of ophthalmology (Am J Ophthalmol) Vol. 112 Issue 5 Pg. 514-9 (Nov 15 1991) ISSN: 0002-9394 [Print] United States
• PMID: 1951587 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Drug Combinations
• Tromethamine
• Ketorolac Tromethamine
• Tolmetin

Topics

• Administration, Topical
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Aphakia (drug therapy, physiopathology)
• Chronic Disease
• Double-Blind Method
• Drug Combinations
• Eye Diseases (chemically induced)
• Humans
• Ketorolac Tromethamine
• Macular Edema (drug therapy, physiopathology)
• Tolmetin (adverse effects, analogs & derivatives, therapeutic use)
• Tromethamine (adverse effects, therapeutic use)
• Visual Acuity