[Severe bacterial keratitis and activity of fluoroquinolones].

Abstract

AIM:

To study the microbiological characteristics of patients with severe bacterial keratitis in Bordeaux, France, as well as the species' resistance to fluoroquinolones.

METHODS:

We conducted a retrospective study of 57 patients presenting severe bacterial keratitis over 20 months. The positive bacteriological cultures of the corneal smears, bacteria, and the antibiogram were listed.

RESULTS:

Fifty-seven patients with severe bacterial keratitis were hospitalized from March 2005 to November 2006. Pseudomonas aeruginosa (n=17), Staphylococcus aureus (n=16), and coagulase-negative Staphylococcus (n=10) were the most frequent species. P. aeruginosa was sensitive in 100% of cases to ciprofloxacin, S. aureus was sensitive in 94% of cases to ciprofloxacin, and coagulase-negative Staphylococcus species were sensitive in 100% of cases to ciprofloxacin. No significant different was noted between ciprofloxacin, levofloxacin, and moxifloxacin on the bacteria studied (p>0.05).

CONCLUSION:

In this study, except for the Streptococcus species, ciprofloxacin was effective against the species responsible for severe bacterial keratitis.

• Authors: N Mesplié, J Kérautret, S Léoni, V Dubois, J Colin
• Journal: Journal francais d'ophtalmologie (J Fr Ophtalmol) Vol. 32 Issue 4 Pg. 273-6 (Apr 2009) ISSN: 1773-0597 [Electronic] France
• Vernacular Title: Kératites bactériennes sévères et sensibilité des germes aux fluoroquinolones.
• PMID: 19515343 (Publication Type: English Abstract, Journal Article)

Chemical References

• Anti-Bacterial Agents
• Fluoroquinolones

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Anti-Bacterial Agents (pharmacology)
• Bacteria (drug effects)
• Child
• Child, Preschool
• Fluoroquinolones (pharmacology)
• Humans
• Infant
• Keratitis (microbiology)
• Microbial Sensitivity Tests
• Middle Aged
• Retrospective Studies
• Severity of Illness Index
• Young Adult