Cognitive impairment and cerebral hypoperfusion in a CADASIL patient improved during administration of lomerizine.

Abstract	A 64-year-old woman was admitted to our hospital for recurrent stroke and cognitive impairment and was diagnosed with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Iodine-123 iodoamphetamine single photon emission computed tomography showed hypoperfusion in the whole brain, but cerebral blood flow increased dramatically after the administration of acetazolamide in the cerebral cortex. Lomerizine, a diphenylmethylpiperazine Ca2+ channel blocker, can selectively increase cerebral blood flow. Cognitive decline and cerebral hypoperfusion improved during 2-year administration of lomerizine in this CADASIL patient, and thus, lomerizine is a potential candidate for treating cognitive impairment in CADASIL patients.
Authors	Toshiki Mizuno, Masaki Kondo, Noriko Ishigami, Aiko Tamura, Masahiro Itsukage, Hideyuki Koizumi, Reina Isayama, Akiko Hosomi, Yoshinari Nagakane, Takahiko Tokuda, Eizo Sugimoto, Yo Ushijima, Masanori Nakagawa
Journal	Clinical neuropharmacology (Clin Neuropharmacol) 2009 Mar-Apr Vol. 32 Issue 2 Pg. 113-6 ISSN: 1537-162X [Electronic] United States
PMID	19512965 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Calcium Channel Blockers Dopamine Uptake Inhibitors Iodine Isotopes Piperazines Amphetamine lomerizine
Topics	Amphetamine CADASIL (complications, drug therapy) Calcium Channel Blockers (administration & dosage, pharmacology, therapeutic use) Cerebral Cortex (diagnostic imaging, drug effects, physiopathology) Cognition Disorders (drug therapy, etiology) Diffusion Magnetic Resonance Imaging (methods) Dopamine Uptake Inhibitors Female Humans Iodine Isotopes Middle Aged Piperazines (administration & dosage, pharmacology, therapeutic use) Tomography, Emission-Computed (methods) Tomography, Emission-Computed, Single-Photon (methods)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!