Suppression of xenogeneic graft-versus-host disease by treatment with immunoglobulin-like transcript 3-Fc.

Abstract	Allogeneic hematopoietic cell transplantation represents an important therapy for certain malignant and nonmalignant diseases. However, graft-versus-host disease (GVHD) is a major cause of mortality and morbidity. The search for agents that can efficiently suppress GVHD has been going on for more than half a century. GVHD is particularly strong in xenogeneic donor-recipient combinations, given the unlimited number of potentially immunogenic antigens donor lymphocytes encounter in the host. Using a hu-nonobese diabetic/severe combined immunodeficiency (hu-NOD/SCID) gamma-null model of xenogeneic GVHD, we have demonstrated that treatment with recombinant immunoglobulin-like transcript 3-Fc protein induces the differentiation of CD8(+) T suppressor cells and blocks the cellular and humoral arm of the GVH reaction.
Authors	George Vlad, Michael B Stokes, Zhuoru Liu, Chih-Chao Chang, Hugo Sondermeijer, Elena R Vasilescu, Adriana I Colovai, Pasquale Berloco, Vivette D D'Agati, Lloyd Ratner, Raffaello Cortesini, Nicole Suciu-Foca
Journal	Human immunology (Hum Immunol) Vol. 70 Issue 9 Pg. 663-9 (Sep 2009) ISSN: 1879-1166 [Electronic] United States
PMID	19501624 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Antibodies, Heterophile Antigens, Heterophile Immunoglobulin Fc Fragments Immunosuppressive Agents LILRB4 protein, human Membrane Glycoproteins Receptors, Cell Surface Receptors, Immunologic Recombinant Fusion Proteins
Topics	Animals Antibodies, Heterophile (immunology) Antigens, Heterophile (immunology) CD8-Positive T-Lymphocytes (immunology, metabolism, pathology) Cell Differentiation (genetics) Disease Progression Female Genetic Engineering Graft vs Host Disease (immunology, physiopathology, therapy) Hematopoietic Stem Cell Transplantation Humans Immunoglobulin Fc Fragments (genetics, immunology, metabolism) Immunosuppressive Agents (immunology, metabolism) Immunotherapy Membrane Glycoproteins Mice Mice, Inbred NOD Mice, SCID Radiation Chimera Receptors, Cell Surface (genetics, immunology, metabolism) Receptors, Immunologic Recombinant Fusion Proteins (genetics, immunology, metabolism) T-Lymphocytes, Regulatory (immunology, metabolism, pathology)

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