Abstract | GOAL: METHODS: A literature search was conducted during July to September 2008 in PubMed, using the query terms "saliva substitute", "saliva substitute and xerostomia", " artificial saliva", and " artificial saliva and xerostomia"; for clinical studies, only studies in patients suffering from radiation-induced xerostomia have been included in the review. RESULTS AND CONCLUSION: Fifty-two studies met the inclusion criteria and were allotted either to the in vitro topics "viscosity", "lubrication", "wetting properties", "antimicrobial effects", and "enamel and dentin de- and remineralization", or to the in vivo topics "clinical acceptance" or "influence on plaque formation and oral mucosa and microflora". The findings suggest that there are significant differences in the performance of various saliva substitutes concerning the review parameters, yet indicate that further in vitro and in vivo studies on the properties of saliva substitutes are necessary.
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Authors | Sebastian Hahnel, Michael Behr, Gerhard Handel, Ralf Bürgers |
Journal | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
(Support Care Cancer)
Vol. 17
Issue 11
Pg. 1331-43
(Nov 2009)
ISSN: 1433-7339 [Electronic] Germany |
PMID | 19495809
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Head and Neck Neoplasms
(complications, radiotherapy)
- Humans
- Radiation Injuries
(complications, drug therapy)
- Saliva, Artificial
(therapeutic use)
- Salivation
(radiation effects)
- Tooth Remineralization
- Treatment Outcome
- Xerostomia
(drug therapy, etiology)
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