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Establishment of reference serum insulin-like growth factor-I and insulin-like growth factor binding protein-3 levels of Tunisian children during childhood and adolescence.

AbstractBACKGROUND:
The aim of the present study is to establish age- and sex-related reference ranges of serum IGF-I and IGF binding protein-3 (IGFBP-3) levels in a pattern of Tunisian children.
SUBJECTS AND METHODS:
Two hundred healthy Tunisian children (103 boys and 97 girls), aged between 6 and 16 yr, were considered in the study.
RESULTS:
Mean serum levels of IGF-I and IGFBP-3 are observed to be higher in girls compared to boys of the same age interval. However, these differences were statistically significant only in pubertal ages (11-14 yr) for IGF-I and in pre-pubertal ages (6-10 yr) for IGFBP- 3 (p<0.05). Steeper variations in IGF-I concentrations were obtained earlier in girls than in boys (11-12 vs 12-13 yr, Tanner stage 3-4). Peak of IGF-I levels are observed at almost the same age interval (12-14 yr). IGFBP-3 levels significantly increased at steeper variations of IGF-I for both sexes followed by steady values.
CONCLUSIONS:
Variations of IGF-I and IGFBP- 3 with the considered parameters (sex, age, and puberty stage), which concord with previous studies on various populations, emphasize the importance of locally established reference levels to construct a SD score prediction model. Establishment of reference serum IGF-I and IGFBP-3 ranges during childhood and adolescence in Tunisian subjects can help to enhance the diagnostic efficiency of IGF-I and IGFBP-3 in evaluating growth disorders in our population.
AuthorsS Sfar, M Zaouali Ajina, S Ben Mdalla, A Baklouti, H Knani, Z Tabka, A Zbidi
JournalJournal of endocrinological investigation (J Endocrinol Invest) Vol. 32 Issue 8 Pg. 671-6 (Sep 2009) ISSN: 1720-8386 [Electronic] Italy
PMID19494704 (Publication Type: Journal Article)
Chemical References
  • Insulin-Like Growth Factor Binding Protein 3
  • Insulin-Like Growth Factor I
Topics
  • Adolescent
  • Age Factors
  • Child
  • Female
  • Humans
  • Insulin-Like Growth Factor Binding Protein 3 (blood)
  • Insulin-Like Growth Factor I (metabolism)
  • Male
  • Puberty (physiology)
  • Reference Values
  • Sex Factors
  • Tunisia

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