Abstract | BACKGROUND: METHODS: Using the hepatitis C virus (HCV) culture system, we have tested the anti-HCV activity of each interferon alpha subtypes. We have analyzed the effect of each subtype on the HCV multiplication and the cell-signaling pathway for some subtypes. RESULTS: There were divergent effects of IFN alpha subtypes against HCV. We have found that IFN alpha 17 was three times more efficient than IFN alpha 2a on HCV. This efficiency was related to a stronger stimulation of the Jak-Stat pathway. CONCLUSION: We suggest that IFN alpha17 should be tested therapeutically with a view to improving treatment efficacy.
|
Authors | Aurelie Dubois, Catherine François, Veronique Descamps, Carole Fournier, Czeslaw Wychowski, Jean Dubuisson, Sandrine Castelain, Gilles Duverlie |
Journal | Virology journal
(Virol J)
Vol. 6
Pg. 70
(Jun 03 2009)
ISSN: 1743-422X [Electronic] England |
PMID | 19493343
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antiviral Agents
- IFNA17 protein, human
- Interferon-alpha
|
Topics |
- Antiviral Agents
(pharmacology)
- Cell Line
- Hepacivirus
(drug effects)
- Hepatocytes
(virology)
- Humans
- Interferon-alpha
(pharmacology)
- Microbial Sensitivity Tests
|