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Comparing the efficacy in reducing dentin hypersensitivity of a new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride to a commercial sensitive toothpaste containing 2% potassium ion: an eight-week clinical study on Canadian adults.

AbstractOBJECTIVE:
This paper presents the results of one of two eight-week dentin hypersensitivity clinical studies in which the efficacy of a novel toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride as sodium monofluorophosphate (MFP) was compared to that of a benchmark commercial toothpaste containing 2% potassium ion, dosed as 3.75% potassium chloride, and 1450 ppm fluoride as sodium fluoride (NaF).
METHODS:
An eight-week clinical study, with seventy-seven patients, was conducted in Mississauga, Canada using a double-blind, stratified, two-treatment design. Tactile sensitivity assessments, as well as air blast sensitivity assessments, were used to compare the efficacy of the two products.
RESULTS:
This clinical study demonstrated that the new toothpaste, containing 8.0% arginine and 1450 ppm MFP in a calcium carbonate base, provided a significant reduction in dentin hypersensitivity when used over a period of eight weeks. The study also showed that this new arginine toothpaste provided significantly greater reductions (p < 0.05) in dentin hypersensitivity in response to tactile (16.2%, 22.4%, and 21.4%) and air blast (16.2%, 29.2%, and 63.4%) stimuli than the benchmark commercial toothpaste containing 2% potassium ion and 1450 ppm NaF in a silica base, after two, four, and eight weeks of product use, respectively.
CONCLUSION:
A new toothpaste containing 8.0% arginine, calcium carbonate, and 1450 ppm fluoride, as sodium monofluorophosphate (MFP), provides significantly greater hypersensitivity relief (p < 0.05) compared to a commercial sensitive toothpaste containing 2% potassium ion after two, four, and eight weeks of product use.
AuthorsFarid Ayad, Nuhad Ayad, Yun Po Zhang, William DeVizio, Diane Cummins, Luis R Mateo
JournalThe Journal of clinical dentistry (J Clin Dent) Vol. 20 Issue 1 Pg. 10-6 ( 2009) ISSN: 0895-8831 [Print] United States
PMID19489187 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Drug Combinations
  • Phosphates
  • Toothpastes
  • fluorophosphate
  • Potassium Chloride
  • Silicon Dioxide
  • Sodium Fluoride
  • Arginine
  • Calcium Carbonate
  • Fluorides
  • Potassium
Topics
  • Adolescent
  • Adult
  • Aged
  • Air
  • Arginine (administration & dosage, therapeutic use)
  • Calcium Carbonate (administration & dosage, therapeutic use)
  • Dentin Sensitivity (prevention & control)
  • Double-Blind Method
  • Drug Combinations
  • Female
  • Fluorides (administration & dosage, therapeutic use)
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Ontario
  • Phosphates (administration & dosage, therapeutic use)
  • Potassium (therapeutic use)
  • Potassium Chloride (administration & dosage, therapeutic use)
  • Silicon Dioxide
  • Sodium Fluoride (administration & dosage, therapeutic use)
  • Toothpastes (therapeutic use)
  • Touch
  • Treatment Outcome
  • Young Adult

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