Abstract | BACKGROUND: METHODS: RESULTS: We investigated 197 paired maternal delivery and cord blood samples. The mean maternal age was 30.8 years, and the mean gestational age was 39.3 weeks. Cord geometric mean concentrations (GMCs) were 0.23 microg/mL for N. meningitidis serogroup C and 0.53 microg/mL for H. influenzae type B. Cord GMCs to diphtheria and tetanus were 0.16 and 1.06 IU/mL, respectively, and cord GMCs to pertussis toxin, filamentous hemagglutinin, and pertactin were 16.2, 34.8, and 17.7 ELISA U/mL (by ELISA), respectively. Cord GMCs to polysaccharide were, in general, 107% identical to maternal GMCs, whereas cord GMCs to proteins were a mean of 157% of maternal concentrations. In addition, the levels of anti-N. meningitidis serogroup C immunoglobulin G1 and G2 in cord blood were 145% and 109% of maternal concentrations, respectively. CONCLUSIONS: Antibody concentrations directed toward polysaccharide were equal in maternal and cord blood, whereas antibody concentrations to proteins were 1.6 times higher in cord blood than in maternal blood. This is probably attributable to the less-active transportation of immunoglobulin G2 antibodies elicited by polysaccharide. Despite proper placental transfer, cord antibody concentrations are low, possibly placing neonates at risk before they receive their primary vaccinations. CLINICAL TRIALS REGISTRATION: ISRCTN14204141 .
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Authors | Richarda M de Voer, Fiona R M van der Klis, Judith E Nooitgedagt, Florens G A Versteegh, Johannes C M van Huisseling, Debbie M van Rooijen, Elisabeth A M Sanders, Guy A M Berbers |
Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
(Clin Infect Dis)
Vol. 49
Issue 1
Pg. 58-64
(Jul 01 2009)
ISSN: 1537-6591 [Electronic] United States |
PMID | 19480581
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Bacterial
- Diphtheria Toxin
- Immunoglobulin G
- Tetanus Toxin
- Pertussis Toxin
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Topics |
- Adolescent
- Adult
- Antibodies, Bacterial
(blood)
- Blood
(immunology)
- Bordetella pertussis
(immunology)
- Diphtheria Toxin
(immunology)
- Female
- Fetal Blood
(immunology)
- Haemophilus influenzae type b
(immunology)
- Humans
- Immunity, Maternally-Acquired
- Immunoglobulin G
(blood)
- Infant, Newborn
- Male
- Neisseria meningitidis, Serogroup C
(immunology)
- Pertussis Toxin
(immunology)
- Pregnancy
- Seroepidemiologic Studies
- Tetanus Toxin
(immunology)
- Young Adult
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