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Efficacy of triazoles in a murine disseminated infection by Candida krusei.

Abstract
We evaluated the efficacies of posaconazole and voriconazole in comparison with that of amphotericin B in a systemic murine infection by Candida krusei. Posaconazole at 50 mg/kg/day and voriconazole at 40 and 60 mg/kg/day prolonged survival and reduced the fungal tissue burden in the kidneys of mice similarly to amphotericin B at 1.5 mg/kg/day and liposomal amphotericin B at 10 mg/kg/day. None of the treatments tested completely resolved the infection.
AuthorsMarçal Mariné, F Javier Pastor, Carolina Serena, Josep Guarro
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 53 Issue 8 Pg. 3585-8 (Aug 2009) ISSN: 1098-6596 [Electronic] United States
PMID19470509 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antifungal Agents
  • Pyrimidines
  • Triazoles
  • liposomal amphotericin B
  • posaconazole
  • Amphotericin B
  • Voriconazole
Topics
  • Amphotericin B (therapeutic use)
  • Animals
  • Antifungal Agents (therapeutic use)
  • Candida (physiology)
  • Candidiasis (drug therapy, mortality)
  • Kidney (microbiology)
  • Male
  • Mice
  • Pyrimidines (therapeutic use)
  • Random Allocation
  • Triazoles (therapeutic use)
  • Voriconazole

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