Association of interleukin-18 gene polymorphisms with hepatitis B virus clearance.
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| Abstract |
The outcome of hepatitis B virus (HBV) infection can be affected by host immune factors. Interleukin-18 (IL-18) was originally discovered as an interferon-gamma-inducing factor and plays a critical role in immune response. We assessed the association between the clearance of HBV infection and single-nucleotide polymorphisms (SNPs) in the IL-18 gene. Between March 2002 and December 2004, a total of 1,050 Korean subjects were enrolled in the study and divided into two groups: (1) the HBV spontaneous recovery group (n = 320) and (2) the chronic HBV carrier group (n = 730). We analyzed SNPs at four polymorphic sites in the IL-18 gene at positions -667G>T, -148G>C, +8925C>G, and +13925A>C. We observed that the subjects bearing the IL-18 -148C allele [odds ratio (OR), 0.25; confidence interval (CI), 0.09-0.68; P = 0.01], the +8925G allele (OR, 0.36; CI, 0.15-0.88; P = 0.02), and the +13925C allele (OR, 0.25; CI, 0.13-0.82; P = 0.01) were significantly associated with HBV clearance in a recessive model. This study indicates that the -148C, +8925G, and +13925C alleles of the IL-18 gene are likely associated with HBV clearance in a Korean population.
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| Authors | Jae Youn Cheong, Sung Won Cho, Bermseok Oh, Kuchan Kimm, Kee Myung Lee, Sung Jae Shin, Jung A Lee, Byung Lae Park, Hyun Sub Cheong, Hyoung Doo Shin, Bo Young Cho, Jin Hong Kim |
| Journal | Digestive diseases and sciences (Dig Dis Sci) Vol. 55 Issue 4 Pg. 1113-9 (Apr 2010) ISSN: 1573-2568 [Electronic] United States |
| PMID | 19466545 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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