Abstract | OBJECTIVE: METHODS: This was a randomized, double-blind, cross-over study conducted in 13 patients of both sexes in the metabolic unit of Hospital das Clínicas de Faculdade de Medicina de Ribeirão Preto-Universídade de São Paulo and was divided into two stages. Three different iron compounds, ferrous sulfate (FS), sodium iron ethylenediaminetetra- acetic acid ( EDTA), and dehydrated cell fraction (DCF), were studied. The patients were randomly assigned to one of four groups receiving high-dose DCF (120mg) and low-dose DCF (5mg) and the two iron compounds. The subjects (n=7) receiving high-dose DCF participated in 2 test days. All patients receiving the physiologic dose (low-dose DCF, n=6) participated in 3 test days with a 1-mo interval between compounds. After an 8-h fast, blood samples were collected at 0.25, 0.5, 1, and 2h. Serum iron curve and the sum of the area under the curve were calculated and adjusted according to a mixed-effect linear model (P<0.05). RESULTS: Serum FS levels were higher in the 120-mg group compared with the others (P<0.005). The mean areas under the curve for FS and EDTA at the doses of 120 and 5mg of elemental iron were 238, 224, 177, and 153 microg/dL, respectively. The mean area under the curve for DCF was 165 microg/dL, with no significant difference between groups. CONCLUSION: Regardless of dose, FS was the compound that resulted in higher ferremia compared with the other doses and compounds.
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Authors | Fabíola Rainato Gabriel, Vivian M M Suen, Julio Sergio Marchini, José Eduardo Dutra de Oliveira |
Journal | Nutrition (Burbank, Los Angeles County, Calif.)
(Nutrition)
2009 Nov-Dec
Vol. 25
Issue 11-12
Pg. 1115-9
ISSN: 1873-1244 [Electronic] United States |
PMID | 19457640
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Ferrous Compounds
- ferrous sulfate
- Edetic Acid
- Iron
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Topics |
- Adult
- Aged
- Area Under Curve
- Brazil
- Cell Fractionation
- Cross-Over Studies
- Dose-Response Relationship, Drug
- Double-Blind Method
- Edetic Acid
(pharmacology)
- Erythrocytes
- Female
- Ferrous Compounds
(administration & dosage, blood)
- Humans
- Iron
(administration & dosage, blood)
- Male
- Middle Aged
- Short Bowel Syndrome
(blood, surgery)
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