Flaxseed oil attenuates nonalcoholic fatty liver of hyperlipidemic hamsters.

Abstract

Hyperlipidemia of hamsters was induced by high-fat/cholesterol diets formulated by the addition of coconut oil (CO), butter (BU), and flaxseed oil (FX). Lower (p < 0.05) serum lipids, liver size, and hepatic cholesterol and triacylglycerol contents were observed in the FX group compared to both CO and BU groups. The liver damage indices [glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) values] in the FX group were lower (p < 0.05) than those in the CO and BU groups, which may result from higher (p < 0.05) glutathione (GSH) levels and a tendency toward lower malondialdehyde (MDA) levels in livers. Besides, lower (p < 0.05) gene expression and activity of hepatic matrix metalloproteinases-9 (MMP-9) in the FX group were lower (p > 0.05) compared to those in the CO and BU groups; however, no (p > 0.05) differences in gene expression activities of hepatic MMP-2 were observed among treatments. Those beneficial effects could explain the attenuation of FX on nonalcoholic fatty liver (NAFL) induced by a high-fat/cholesterol dietary habit.

• Authors: Shun-Fa Yang, Jung-Kai Tseng, Yuan-Yen Chang, Yi-Chen Chen
• Journal: Journal of agricultural and food chemistry (J Agric Food Chem) Vol. 57 Issue 11 Pg. 5078-83 (Jun 10 2009) ISSN: 1520-5118 [Electronic] United States
• PMID: 19453104 (Publication Type: Journal Article)

Chemical References

• Malondialdehyde
• Linseed Oil
• Aspartate Aminotransferases
• Alanine Transaminase
• Matrix Metalloproteinase 2
• Matrix Metalloproteinase 9

Topics

• Alanine Transaminase (genetics, metabolism)
• Animals
• Aspartate Aminotransferases (genetics, metabolism)
• Cricetinae
• Disease Models, Animal
• Fatty Liver (drug therapy, genetics, metabolism)
• Gene Expression (drug effects)
• Humans
• Hyperlipidemias (drug therapy, genetics, metabolism)
• Linseed Oil (administration & dosage)
• Liver (drug effects, enzymology, metabolism)
• Male
• Malondialdehyde (metabolism)
• Matrix Metalloproteinase 2 (genetics, metabolism)
• Matrix Metalloproteinase 9 (genetics, metabolism)
• Mesocricetus