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Further observations on the prevention of experimental proliferative vitreo-retinopathy by 5-fluorouracil.

Abstract
The rate of retinal detachment in fellow control eyes of rabbits following fibroblast administration is progressively lower with increased dose of 5-Fluorouracil in the test eyes. Thus, it seems mandatory to choose control eyes in other animals rather than the fellow eyes of the treated ones. Retinal detachment appeared in the second week or earlier after intravitreal fibroblast administration. However, in eyes treated intravitreally with 5-Fluorouracil, retinal detachment or pucker appeared later, even in the second month suggesting routine follow-up of at least 2 months in future studies.
AuthorsA Ophir
JournalOphthalmic research (Ophthalmic Res) Vol. 23 Issue 3 Pg. 128-32 ( 1991) ISSN: 0030-3747 [Print] Switzerland
PMID1945284 (Publication Type: Journal Article)
Chemical References
  • Fluorouracil
Topics
  • Animals
  • Disease Models, Animal
  • Eye Diseases (prevention & control)
  • Fibroblasts (pathology)
  • Fluorouracil (therapeutic use)
  • Follow-Up Studies
  • Rabbits
  • Retinal Detachment (etiology)
  • Retinal Diseases (prevention & control)
  • Vitreous Body (drug effects)

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