Abstract | OBJECTIVE: DESIGN: SETTING: Academic medical center. SUBJECTS: Acute inflammation was induced by transtympanic injection of heat killed Streptococcus pneumoniae to 100 BALB/c mice. INTERVENTIONS: MAIN OUTCOME MEASURES: RESULTS: Histologic middle ear morphometrics showed significant steroid effects at both 3 and 5 days in reduction of fluid area, cell number, and tympanic membrane thickness. CONCLUSIONS:
Glucocorticoids were most effective in controlling inflammation. Interestingly, the mineralocorticoids were also effective in reducing the inflammatory response at 5 days, suggesting that their fluid transport function helped clear disease. Thus, steroid control of middle ear disease may be useful in alleviating symptoms faster and reducing the risk to the inner ear.
|
Authors | Carol J MacArthur, Jacqueline M DeGagne, J Beth Kempton, Dennis R Trune |
Journal | Archives of otolaryngology--head & neck surgery
(Arch Otolaryngol Head Neck Surg)
Vol. 135
Issue 5
Pg. 453-7
(May 2009)
ISSN: 1538-361X [Electronic] United States |
PMID | 19451465
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
|
Chemical References |
- Glucocorticoids
- Mineralocorticoids
- Aldosterone
- Dexamethasone
- Prednisolone
- Fludrocortisone
|
Topics |
- Aldosterone
(pharmacology)
- Animals
- Dexamethasone
(pharmacology)
- Disease Models, Animal
- Ear, Inner
(drug effects)
- Ear, Middle
(drug effects)
- Fludrocortisone
(pharmacology)
- Glucocorticoids
(pharmacology)
- Mice
- Mice, Inbred BALB C
- Mineralocorticoids
(pharmacology)
- Otitis Media
(drug therapy)
- Prednisolone
(pharmacology)
|