Application of pharmacogenomics to vaccines.

Abstract

The field of pharmacogenomics and pharmacogenetics provides a promising science base for vaccine research and development. A broad range of phenotype/genotype data combined with high-throughput genetic sequencing and bioinformatics are increasingly being integrated into this emerging field of vaccinomics. This paper discusses the hypothesis of the 'immune response gene network' and genetic (and bioinformatic) strategies to study associations between immune response gene polymorphisms and variations in humoral and cellular immune responses to prophylactic viral vaccines, such as measles-mumps-rubella, influenza, HIV, hepatitis B and smallpox. Immunogenetic studies reveal promising new vaccine targets by providing a better understanding of the mechanisms by which gene polymorphisms may influence innate and adaptive immune responses to vaccines, including vaccine failure and vaccine-associated adverse events. Additional benefits from vaccinomic studies include the development of personalized vaccines, the development of novel vaccines and the development of novel vaccine adjuvants.

• Authors: Gregory A Poland, Inna G Ovsyannikova, Robert M Jacobson
• Journal: Pharmacogenomics (Pharmacogenomics) Vol. 10 Issue 5 Pg. 837-52 (May 2009) ISSN: 1744-8042 [Electronic] England
• PMID: 19450131 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Review)

Chemical References

• Cytokines
• Vaccines

Topics

• Child
• Computational Biology
• Cytokines (genetics)
• Genetic Predisposition to Disease (genetics)
• Genetic Variation
• Humans
• Immunization (methods)
• Immunogenetic Phenomena (genetics)
• Measles (genetics, immunology)
• Pharmacogenetics (methods)
• Polymorphism, Single Nucleotide
• Twin Studies as Topic
• Vaccines