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Hypoxia-inducible factor-1 alpha has a key role in hypoxic preconditioning.

Abstract
Sublethal hypoxia induces tolerance to subsequent hypoxic insults in a process known as hypoxic preconditioning (HP). Hypoxia-inducible factor-1 alpha (HIF-1 alpha) is a key transcription protein involved in the mechanism of HP. In this study, we investigated the effects of HP on tissue oxygenation and expression of HIF-1 alpha gene targets in the brain using neural cell-specific HIF-1 alpha-deficient mice. The animals were exposed to 8% oxygen for 3 hours. Twenty-four hours later, the oxygen partial pressure (pO(2)) of brain tissue and gene expression were measured during hypoxia. HP improved the pO(2) of brain tissue during subsequent hypoxia with upregulated inducible nitric oxide synthase in wild-type mice, whereas HP had no detectable effect in the mutant mice. Our results indicate that the protective effects of HP may be partially mediated by improving tissue oxygenation via HIF-1 alpha and inducible nitric oxide synthase.
AuthorsSatoshi Taie, Junichiro Ono, Yasuyuki Iwanaga, Shuhei Tomita, Takehiko Asaga, Kosuke Chujo, Masaaki Ueki
JournalJournal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia (J Clin Neurosci) Vol. 16 Issue 8 Pg. 1056-60 (Aug 2009) ISSN: 0967-5868 [Print] Scotland
PMID19447625 (Publication Type: Journal Article)
Chemical References
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Nitric Oxide Synthase Type II
  • Oxygen
Topics
  • Analysis of Variance
  • Animals
  • Brain (blood supply, enzymology, metabolism)
  • Gene Expression
  • Hypoxia (enzymology, metabolism)
  • Hypoxia-Inducible Factor 1, alpha Subunit (genetics, metabolism)
  • Ischemic Preconditioning
  • Male
  • Mice
  • Mice, Knockout
  • Nitric Oxide Synthase Type II (metabolism)
  • Oxygen (metabolism)
  • Partial Pressure
  • Polymerase Chain Reaction

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