Abstract |
Approximately 10-80% of patients with Cystic Fibrosis (CF) have vitamin D deficiency. Obtaining therapeutic vitamin D levels has been a challenge for CF care providers using current recommended high-dose oral ergocalciferol (400,000 IU over 2 months). The objective of this study was to evaluate the safety and efficacy of a 2-week, very high dose ergocalciferol (700,000 IU over 14 days) repletion strategy in children and young adults with CF. As part of a quality improvement initiative, a prospective cohort study was performed from January through May 2007. Phase I included identifying individuals with CF who were subtherapeutic in 25-OH D. In phase II, 50,000 IU of ergocalciferol was prescribed for a 14 day term and administered daily. During phase III, a post treatment 25-OH D level was obtained to determine improvement. Baseline demographics and clinical characteristics were obtained at study entry. Stratification of the post 25-OHD levels was defined. Eighteen individuals with CF participated in the study. The mean age was 17+/-5 years (range 6-25 years). One hundred percent were pancreatic insufficient and required pancreatic enzyme replacement. All 18 had 25-OHD levels less than 30 ng/mL pre-treatment. Seventeen of the 18 (94%) participants became therapeutic in the 2-week interval. No patients had values considered high abnormal (100-150 ng/mL) or toxic (>150 ng/mL). Mean change was noted at an increase of 37.3+/-22 ng/mL in the 2-week period (p<0.001). Pre and peripubertal individuals had a significantly greater increase in 25-OH D levels. The results of this study demonstrate that very high dosing of vitamin D using oral ergocalciferol over a 14 day period is an effective strategy in achieving therapeutic levels of 25-OH vitamin D in children and young adults with CF. We believe this regimen deserves further study.
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Authors | Steven R Boas, Joseph R Hageman, Louisa T Ho, Marissa Liveris |
Journal | Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
(J Cyst Fibros)
Vol. 8
Issue 4
Pg. 270-2
(Jul 2009)
ISSN: 1873-5010 [Electronic] Netherlands |
PMID | 19447079
(Publication Type: Clinical Trial, Phase I, Clinical Trial, Phase II, Journal Article)
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Chemical References |
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Topics |
- Administration, Oral
- Adolescent
- Adult
- Child
- Cystic Fibrosis
(complications)
- Ergocalciferols
(administration & dosage, adverse effects, blood)
- Female
- Humans
- Male
- Prospective Studies
- Treatment Outcome
- Vitamin D Deficiency
(complications, drug therapy)
- Vitamins
(administration & dosage, adverse effects, blood)
- Young Adult
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