Abstract | BACKGROUND: MATERIAL AND METHODS: RESULTS: All patients with pemphigus vulgaris responded excellently to treatment. Five of the 8 patients achieved complete remission of pemphigus lesions after 10 cycles of cyclophosphamide. In the other 3 patients, the skin lesions disappeared a few weeks after the last cycle of cyclophosphamide. A substantial reduction in immuno suppressant dose was possible in all patients. Furthermore, an improved immunologic response was observed in all cases after cyclophosphamide treatment, with decreased anti-DSG1 and anti-DSG3 antibody titers and well as decreased circulating anti-EIS antibody titers. During the mean 15.1 month follow-up (range, 1-25 months), no new lesions appeared and no side effects of cyclophosphamide therapy were reported. CONCLUSIONS:
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Authors | Agustín España Alonso, C Panizo, S Fernández, M Marquina, M Pretel, L Aguado, A Sánchez-Ibarrola |
Journal | Actas dermo-sifiliograficas
(Actas Dermosifiliogr)
Vol. 100
Issue 2
Pg. 113-20
(Mar 2009)
ISSN: 0001-7310 [Print] Spain |
Vernacular Title | Remisión clínica completa prolongada en pacientes con pénfigo vulgar grave después del tratamiento con ciclos intravenosos de ciclofosfamida. |
PMID | 19445875
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Adrenal Cortex Hormones
- Autoantibodies
- Autoantigens
- DSG1 protein, human
- DSG3 protein, human
- Desmoglein 1
- Desmoglein 3
- Immunosuppressive Agents
- Cyclophosphamide
- Mycophenolic Acid
- Azathioprine
- Methotrexate
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Topics |
- Adrenal Cortex Hormones
(administration & dosage, therapeutic use)
- Adult
- Autoantibodies
(blood, immunology)
- Autoantigens
(immunology)
- Azathioprine
(administration & dosage, therapeutic use)
- Cyclophosphamide
(administration & dosage, adverse effects, therapeutic use)
- Desmoglein 1
(immunology)
- Desmoglein 3
(immunology)
- Drug Administration Schedule
- Drug Therapy, Combination
- Female
- Humans
- Immunosuppressive Agents
(administration & dosage, adverse effects, therapeutic use)
- Injections, Intravenous
- Male
- Methotrexate
(administration & dosage, therapeutic use)
- Middle Aged
- Mycophenolic Acid
(administration & dosage, analogs & derivatives, therapeutic use)
- Nausea
(chemically induced)
- Pemphigus
(drug therapy)
- Remission Induction
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