Abstract |
Mother-to-child transmission during pregnancy provides a unique system for studying the correlation between HLA phenotype and susceptibility to HIV infection. We studied this relationship in a Spanish cohort. We determined frequencies of HLA class I and II alleles in 120 infants born to HIV-infected mothers and 67 HIV-infected mothers. Although there was no statistical difference in the frequency of HLA-B35 between transmitting and non-transmitting mothers, the allele was more frequent in infected children than in uninfected children. HLA-B35 has been consistently reported as a risk factor in the progression to AIDS. In addition, it has been proposed that whether a given allele can confer susceptibility to, or protection against, progression depends on maternal versus paternal inheritance patterns, since the child inherits a virus that reflects the history of CTL encounters of the mother. Our results on vertical HIV transmission combine for the first time the 'HLA-B35 disadvantage' and the 'pattern of inheritance' theories.
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Authors | Antonio Arnaiz-Villena, José Manuel Martín-Villa, José Tomás Ramos Amador, Almudena Cendoya-Matamoros, María Isabel González Tomé, José María Rivera, Narcisa Martinez-Quiles |
Journal | Current HIV research
(Curr HIV Res)
Vol. 7
Issue 3
Pg. 314-9
(May 2009)
ISSN: 1873-4251 [Electronic] Netherlands |
PMID | 19442128
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- HLA-B35 Antigen
- HLA-C Antigens
- HLA-C*04 antigen
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Topics |
- Adult
- Cohort Studies
- Disease Susceptibility
- Female
- Gene Frequency
- HIV Infections
(transmission)
- HLA-B35 Antigen
(genetics)
- HLA-C Antigens
(genetics)
- Humans
- Infant, Newborn
- Infectious Disease Transmission, Vertical
- Risk Factors
- Spain
- Young Adult
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