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Risk of vertical HIV transmission combines the 'B35-Cw4 disadvantage' and the 'pattern of inheritance' theories of progression.

Abstract
Mother-to-child transmission during pregnancy provides a unique system for studying the correlation between HLA phenotype and susceptibility to HIV infection. We studied this relationship in a Spanish cohort. We determined frequencies of HLA class I and II alleles in 120 infants born to HIV-infected mothers and 67 HIV-infected mothers. Although there was no statistical difference in the frequency of HLA-B35 between transmitting and non-transmitting mothers, the allele was more frequent in infected children than in uninfected children. HLA-B35 has been consistently reported as a risk factor in the progression to AIDS. In addition, it has been proposed that whether a given allele can confer susceptibility to, or protection against, progression depends on maternal versus paternal inheritance patterns, since the child inherits a virus that reflects the history of CTL encounters of the mother. Our results on vertical HIV transmission combine for the first time the 'HLA-B35 disadvantage' and the 'pattern of inheritance' theories.
AuthorsAntonio Arnaiz-Villena, José Manuel Martín-Villa, José Tomás Ramos Amador, Almudena Cendoya-Matamoros, María Isabel González Tomé, José María Rivera, Narcisa Martinez-Quiles
JournalCurrent HIV research (Curr HIV Res) Vol. 7 Issue 3 Pg. 314-9 (May 2009) ISSN: 1873-4251 [Electronic] Netherlands
PMID19442128 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • HLA-B35 Antigen
  • HLA-C Antigens
  • HLA-C*04 antigen
Topics
  • Adult
  • Cohort Studies
  • Disease Susceptibility
  • Female
  • Gene Frequency
  • HIV Infections (transmission)
  • HLA-B35 Antigen (genetics)
  • HLA-C Antigens (genetics)
  • Humans
  • Infant, Newborn
  • Infectious Disease Transmission, Vertical
  • Risk Factors
  • Spain
  • Young Adult

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