[Antioxidant and membranoprotective properties of trolox].

Abstract

The antioxidant and membranoprotective properties of trolox have been studied in vitro. It is established that trolox possesses antioxidant properties, inhibiting ascorbate-dependent lipid peroxidation of liver homogenates and Fe(2+)-induced lipid chemiluminescence of egg-yolk lipids. In addition, trolox exhibits a broad spectrum of antiradical activity and interacts with stable free 2,2-diphenyl-1-picrylhydrazyl radical so as to reduce the generation of luminol radicals and reactive oxygen species and to bind peroxy radicals. Trolox also possessed membranoprotective properties, being capable of reducing the oxidative hemolysis of erythrocytes.

• Authors: E V Tibir'kova, V A Kosolapov, A A Spasov
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2009 Mar-Apr Vol. 72 Issue 2 Pg. 47-50 ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 19441730 (Publication Type: Journal Article)

Chemical References

• Antioxidants
• Biphenyl Compounds
• Chromans
• Free Radicals
• Picrates
• 1,1-diphenyl-2-picrylhydrazyl
• 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid

Topics

• Animals
• Antioxidants (pharmacology)
• Biphenyl Compounds
• Chick Embryo
• Chromans (pharmacology)
• Egg Yolk (metabolism)
• Erythrocyte Membrane (drug effects, physiology)
• Free Radicals
• Hemolysis
• Lipid Peroxidation (drug effects)
• Liver (drug effects, metabolism)
• Luminescent Measurements
• Picrates
• Rats