Prospective, open-label, comparative study of clindamycin 1%/benzoyl peroxide 5% gel with adapalene 0.1% gel in Asian acne patients: efficacy and tolerability.

Abstract

BACKGROUND:

Used as individual agents, topical antibiotics and benzoyl peroxide are known to be effective in treatment of acne. Clindamycin phosphate 1% with benzoyl peroxide 5% (CDP/BPO) is a new combination gel, made by rationale, in that combination drug is more effective than either ingredients used alone. Adapalene 0.1% (ADA) is the third-generation retinoid, shown to be as effective as other topical retinoid with well tolerability.

OBJECTIVES:

To compare the efficacy and tolerability in combination of CDP/BPO in comparison with ADA in Asian patients with mild to moderate acne vulgaris.

METHODS:

Total of 69 patients, including 31 patients for CDP/BPO group and 38 for ADA group, with mild to moderate acne vulgaris were enrolled for a 12-week prospective, randomized, open-label comparative study of topical agents. Efficacy was assessed by lesion counts, acne grading system, and global improvement. Adverse events were also evaluated in scale of 0 (none) to 3 (severe).

RESULTS:

Both CDP/BPO and ADA were effective in reducing lesion counts and acne severity scale and showed significant global improvement. However, CDP/BPO offered greater efficacy against inflammatory lesions than ADA. Both drugs were well tolerated with minimal adverse drug reactions.

CONCLUSION:

Combination formulation of CDP/BPO and ADA were shown to be both effective in decreasing total, inflammatory, and non-inflammatory lesion counts along with well tolerability in Asian patients with mild to moderate acne vulgaris.

• Authors: H-C Ko, M Song, S-H Seo, C-K Oh, K-S Kwon, M-B Kim
• Journal: Journal of the European Academy of Dermatology and Venereology : JEADV (J Eur Acad Dermatol Venereol) Vol. 23 Issue 3 Pg. 245-50 (Mar 2009) ISSN: 1468-3083 [Electronic] England
• PMID: 19438817 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Drug Combinations
• Gels
• Naphthalenes
• Adapalene
• Clindamycin
• Benzoyl Peroxide

Topics

• Acne Vulgaris (drug therapy)
• Adapalene
• Adult
• Benzoyl Peroxide (administration & dosage, therapeutic use)
• Clindamycin (administration & dosage, therapeutic use)
• Drug Combinations
• Female
• Gels
• Humans
• Male
• Naphthalenes (administration & dosage, therapeutic use)
• Prospective Studies