Abstract | BACKGROUND: METHODS: We compared duplex sonographic measurements in renal allograft recipients (30 males, 20 females) from living donors randomized to a losartan (25 mg twice daily) or a control group. RESULTS: The patients in the two groups had similar baseline characteristics, and 49 (24 in the losartan and 25 in the control group) completed 12 months of follow-up. After 12 months, the losartan and control groups did not differ significantly in mean RI (0.71 +/- 0.06 vs 0.69 +/- 0.07, P = 0.4) or PI (1.3 +/- 0.25 vs 1.29 +/- 0.28, P = 0.8) of the intrarenal artery and mean RI (0.74 +/- 0.07 vs 0.72 +/- 0.07, P = 0.3) and PI (1.5 +/- 0.3 vs 1.4 +/- 0.34, P = 0.3) of the main artery. CONCLUSIONS:
Losartan had no effect on Doppler sonography indices. Longer follow-up, however, may be needed to confirm this finding.
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Authors | Nader Nouri-Majalan, Reza Nafisi, Sarasadat Moghadasi-Mousavi |
Journal | Vascular health and risk management
(Vasc Health Risk Manag)
Vol. 5
Issue 1
Pg. 97-100
( 2009)
ISSN: 1178-2048 [Electronic] New Zealand |
PMID | 19436681
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Angiotensin II Type 1 Receptor Blockers
- Losartan
|
Topics |
- Adult
- Angiotensin II Type 1 Receptor Blockers
(therapeutic use)
- Female
- Humans
- Kidney Transplantation
- Losartan
(therapeutic use)
- Male
- Middle Aged
- Renal Artery
(diagnostic imaging, drug effects, physiopathology, surgery)
- Renal Circulation
(drug effects)
- Time Factors
- Ultrasonography, Doppler, Color
- Vascular Resistance
(drug effects)
- Young Adult
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